| Identification | Back Directory | [Name]
YK5 | [CAS]
1268273-23-9 | [Synonyms]
YK5
N-(6-Amino-2-((4,6-dimethoxy-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)thio)pyrimidin-4-yl)acrylamide
2-Propenamide, N-[6-amino-2-[[4,6-dimethoxy-2-(4-methyl-1-piperazinyl)-5-pyrimidinyl]thio]-4-pyrimidinyl]- | [Molecular Formula]
C18H24N8O3S | [MDL Number]
MFCD28160862 | [MOL File]
1268273-23-9.mol | [Molecular Weight]
432.5 |
| Hazard Information | Back Directory | [Uses]
YK5 is a potent and selective Hsp70 inhibitor. YK5 selectively and tightly binds to the cytosolic Hsp70s in cancer cells. YK5 has biological activity partly by interfering with the formation of active oncogenic Hsp70/Hsp90/client protein complexes[1]. | [IC 50]
HSP70; HSP90 | [References]
[1] Rodina A, et al. Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein. Chem Biol. 2013 Dec 19;20(12):1469-80. DOI:10.1016/j.chembiol.2013.10.008 |
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