| Identification | Back Directory | [Name]
1-PYRIDIN-4-YLPIPERIDIN-4-ONE | [CAS]
126832-81-3 | [Synonyms]
1-PYRIDIN-4-YLPIPERIDIN-4-ONE
1-pyridin-4-yl-4-piperidinone
1-(4-Pyridinyl)-4-piperidinone
4-Piperidinone, 1-(4-pyridinyl)-
2,3,5,6-TETRAHYDRO-[1,4']BIPYRIDINYL-4-ONE | [Molecular Formula]
C10H12N2O | [MDL Number]
MFCD09030756 | [MOL File]
126832-81-3.mol | [Molecular Weight]
176.22 |
| Chemical Properties | Back Directory | [Boiling point ]
340.8±32.0 °C(Predicted) | [density ]
1.163±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
10.54±0.10(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 1-(4-pyridyl)-piperidin-4-one from the compound (CAS:166954-75-2) was as follows: 79.7 g of the aforementioned ketone was dissolved in 2 L of tetrahydrofuran, followed by the addition of 1000 mL of 6 N hydrochloric acid solution. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the solvent was removed by evaporation and concentration, and the pH was adjusted to alkaline with semi-concentrated ammonia. Extraction was carried out using dichloromethane and the combined organic phases were concentrated by evaporation to give 64.2 g (quantitative yield) of 2,3,5,6-tetrahydro-[1,4']bipyridin-4-one, which has a melting point of 102 °C. | [References]
[1] Patent: US2003/236266, 2003, A1. Location in patent: Page 7
[2] European Journal of Medicinal Chemistry, 2017, vol. 139, p. 128 - 152
[3] Patent: WO2010/81851, 2010, A1. Location in patent: Page/Page column 17
[4] Patent: US2012/71461, 2012, A1. Location in patent: Page/Page column 147
[5] Tetrahedron Letters, 2007, vol. 48, # 14, p. 2519 - 2525 |
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SynAsst Chemical.
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