| Identification | Back Directory | [Name]
Thiobenzanilide-63T | [CAS]
1270966-08-9 | [Synonyms]
63T
Thiobenzanilide63T
Thiobenzanilide-63T
Thiobenzanilide 63T | [Molecular Formula]
C20H10F6N2S2 | [MOL File]
1270966-08-9.mol | [Molecular Weight]
456.43 |
| Hazard Information | Back Directory | [Description]
Thiobenzanilide 63T is a small molecule compound, which selectively induces cancer cell death in a caspase independent pathway. | [Uses]
Thiobenzanilide 63T (63T) is a small molecule that selectively induces cancer cell death in a caspase-independent pathway. Thiobenzanilide 63T induces reactive oxygen species and lipid peroxidation. Thiobenzanilide 63T demonstrates strong cytotoxic activity against a lung-derived cancer cell line. Thiobenzanilide 63T decreases the expression of heme oxygenase (HO-1) in A549 cells[1][2]. | [References]
[1] Kucinska M, et al. Selective anticancer activity of the novel thiobenzanilide 63T against human lung adenocarcinoma cells. Toxicol In Vitro. 2016 Dec;37:148-161. DOI:10.1016/j.tiv.2016.09.017
[2] Kucinska M, et al. The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines. Invest New Drugs. 2019 Oct;37(5):849-864. DOI:10.1007/s10637-018-0704-8 |
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