| Identification | Back Directory | [Name]
Glycine, L-γ-glutamyl-S-[2-[[4-(dihydroxyarsino)phenyl]amino]-2-oxoethyl]-L-cysteinyl- | [CAS]
1271726-51-2 | [Synonyms]
GSAO
Glycine, L-γ-glutamyl-S-[2-[[4-(dihydroxyarsino)phenyl]amino]-2-oxoethyl]-L-cysteinyl- | [Molecular Formula]
C18H25AsN4O9S | [MDL Number]
MFCD32644216 | [MOL File]
1271726-51-2.mol | [Molecular Weight]
548.4 |
| Hazard Information | Back Directory | [Uses]
Glutathione arsenoxide (GSAO) is a potential anticancer agent and a tumour metabolism inhibitor. Glutathione arsenoxide targets Mitochondrial endomycin nucleotide transferase (ANT). Glutathione arsenoxide causes cell proliferation arrest and cell death. Glutathione arsenoxide can be used to identify cell-surface proteins, such as Protein disulphide isomerase[1][2]. | [Definition]
ChEBI: S-{2-[4-(dihydroxyarsino)phenylamino]-2-oxoethyl}-glutathione is a glutathione derivative. It is functionally related to a p-aminophenylarsonous acid. | [References]
[1] Park D, et al. The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase. Cancer Cell Int. 2012 Mar 26;12(1):11. DOI:10.1186/1475-2867-12-11
[2] Habeck M. Australian scientists design novel antiangiogenic weapon[J]. The Lancet Oncology, 2000, 1(4): 199. |
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