| Identification | Back Directory | [Name]
Biofor 389 | [CAS]
127245-22-1 | [Synonyms]
BF 389
Biofor 389
2H-1,2-Oxazin-3(4H)-one, 4-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]dihydro-2-methyl- | [Molecular Formula]
C20H29NO3 | [MDL Number]
MFCD00902841 | [MOL File]
127245-22-1.mol | [Molecular Weight]
331.45 |
| Hazard Information | Back Directory | [Uses]
BF389 (Biofor 389) is an orally active anti-inflammatory and analesis agent. BF389 is also an inhibitor of cyclooxygenase and 5-lipoxygenase, with IC50s of 4 and 8 ug/mL for COX-1 and COX-2 respectively. BF389 can be used for arthritis research[1][2][3]. | [in vivo]
BF389 (1-30 mg/kg, p.o., five daily oral doses) inhibits paw swelling in rats, with an ED50 of 4.9 mg/kg, indicating the anti-inflammatory activity[1].
| [IC 50]
COX-1: 4 μg/mL (IC50); COX-2: 8 μg/mL (IC50); 5-LOX | [References]
[1] Bendele AM, et al. Anti-inflammatory activity of BF389, a Di-T-butylphenol, in animal models of arthritis. J Pharmacol Exp Ther. 1992 Jan;260(1):300-5. PMID:1309875
[2] Wong S, et al. Antiarthritic profile of BF-389--a novel anti-inflammatory agent with low ulcerogenic liability. Agents Actions. 1992 Sep;37(1-2):90-8. DOI:10.1007/BF01987895
[3] Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7. DOI:10.1073/pnas.90.24.11693 |
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