| Identification | Back Directory | [Name]
1-phenyl-2,5,8,11-tetraoxatetradecan-14-oicacid | [CAS]
127457-64-1 | [Synonyms]
Benzyl-PEG4-acid
BnO-PEG3-CH2CH2COOH
BnO-(CH2CH2O)3-CH2CH2COOH
1-phenyl-2,5,8,11-tetraoxatetradecan-14-oicacid
1-phenyl-2,5,8,11-tetraoxatetradecan-14-oicacid(WXPC0056) | [Molecular Formula]
C16H24O6 | [MDL Number]
MFCD31561129 | [MOL File]
127457-64-1.mol | [Molecular Weight]
312.36 |
| Chemical Properties | Back Directory | [Boiling point ]
454.3±40.0 °C(Predicted) | [density ]
1.138±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Benzyl-PEG4-acid is a PEG linker containing a benzyl protecting group and a carboxylic acid group. Benzyl is an alcohol protecting group and can be removed via hydrogenolysis. The carboxylic acid group can react with primary amine groups in the presence of activators such as EDC or HATU to form a stable amide bond. | [Uses]
Benzyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. | [References]
[1] Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67. DOI:10.3762/bjoc.11.74 |
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