| Identification | Back Directory | [Name]
mexidol | [CAS]
127464-43-1 | [Synonyms]
mexidol
Mexifin
Mexidole
Mexiletine base
Methoxyl west dol
Mexidol succinate
Emoxypine Succinate
mexidol ISO 9001：2015 REACH
Emoxypine Succinate (Mexidol)
Emoxypine Succinate (Mexifin)
ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE
2-Ethyl-6-Methylpyridin-3-ol succinate
2-Ethyl-6-Methyl-3-pyridinol butanoate
2-Ethyl-6-methylpyridine-3-ol succinate
2-Ethyl-3-hydroxy-6-methylpyridine Succinate
2-Ethyl-6-methyl-3-pyridinol butanoate (1:1)
2-Ethyl-6-methyl-3-hydroxypyridine succinate
High purity CAS 127464-43-1 mexidol in stock
2-Ethyl-6-methyl-3-pyridinol succinate (salt)
2-Ethyl-3-hydroxy-6-methylpyridineSuccinate>
Butanedioic acid 2-ethyl-6-methyl-3-pyridinol (1:1)
2-ethyl-6-Methyl-3-hydroxypyridine succinate (Mexidole)
Mexidole (2-ethyl-6-Methyl-3-hydroxypyridine succinate)
Mexidole(2-ethyl-6-ChemicalbookMethyl-3-hydroxypyridinesuccinate) | [EINECS(EC#)]
811-046-3 | [Molecular Formula]
C8H11NO.C4H6O4 | [MDL Number]
MFCD00445612 | [MOL File]
127464-43-1.mol | [Molecular Weight]
255.268 |
| Chemical Properties | Back Directory | [Melting point ]
119-120 °C | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [InChI]
InChI=1S/C8H11NO.C4H6O4/c1-3-7-8(10)5-4-6(2)9-7;5-3(6)1-2-4(7)8/h4-5,10H,3H2,1-2H3;1-2H2,(H,5,6)(H,7,8) | [InChIKey]
IKMNOGHPKNFPTK-UHFFFAOYSA-N | [SMILES]
C1(CC)N=C(C=CC=1O)C.C(C(=O)O)CC(=O)O |
| Hazard Information | Back Directory | [Uses]
The Chinese name of Mesidol is 2-ethyl-6methyl-3-hydroxypyridine succinic acid (Mexidox), 2-ethyl-6-methyl-3-hydroxypyridine succinate (emoxypine, product Name-MEXIDOL?, etc.) is widely used in medicine as an antioxidant and anti-hypoxic agent. Use 2-ethyl-6-methyl-3-hydroxypyridine succinate as a nootropic and anxiolytic, anti-ischemic and atherosclerotic, anti-angina, liver protection, antibacterial, etc. | [Preparation]
3.5 liters of ethanol, 1.2 kg of 2-ethyl-6-methyl-3-hydroxypyridine and 1.0 kg of succinic acid were added to the reactor. The reaction mass is heated to the boiling point of ethanol (78°C) and stirring is continued for 20 minutes until the components are completely dissolved. Then, keep the reaction mass in the reactor under stirring until the temperature reaches 20°C, cool to 5°C and keep at this temperature for 16 hours, stirring occasionally. The suspension is then stirred until the material is homogeneous, overloaded in a centrifuge and filtered. The precipitate of the succinate salt of 2-ethyl-6-methyl-3-hydroxypyridine was dried to constant weight in a vacuum oven at 45°C. The yield of the target product 2-ethyl-6-methyl-3-hydroxypyridine succinate (Mexitrad) was 89%. | [in vivo]
Emoxypine succinate (i.p.; 40 mg/kg; 1 time per day, 14 days) decreases the production of reactive oxygen species, mitochondrial transmembrane potential percentage of leukocyte and the percentage of FITC Annexin V- positive cells of leukocyte suspension[1]. | Animal Model: | Rats[1] | | Dosage: | 40 mg/kg | | Administration: | Intraperitoneal, 1 time per day, 14 days | | Result: | Significantly increased the percentage of Annexin V-positive cells, reduced the apoptotic percentage of white blood cells and decreased the production of reactive oxygen species by leukocytes. |
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| Company Name: |
SynAsst Chemical.
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| Telephone: |
021-60343070 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
| Company Name: |
Jinan Putubio Tech Co., Ltd.
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| Telephone: |
+86 (531) 8099-2215 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList16923/0_EN.htm |
| Company Name: |
parabiochem
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| Telephone: |
025-83453382-8005 |
| Website: |
www.parabiochem.cn |
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