| Identification | Back Directory | [Name]
cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine | [CAS]
127757-45-3 | [Synonyms]
Cyclic HPMPC
cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine
2(1H)-Pyrimidinone, 4-amino-1-[[(5S)-2-hydroxy-2-oxido-1,4,2-dioxaphosphorinan-5-yl]methyl]- | [Molecular Formula]
C8H12N3O5P | [MOL File]
127757-45-3.mol | [Molecular Weight]
261.17 |
| Hazard Information | Back Directory | [Uses]
Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain)-infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model[1][2]. | [References]
[1] Smee DF, et al. Effects of four antiviral substances on lethal vaccinia virus (IHD strain) respiratory infections in mice. Int J Antimicrob Agents. 2004;23(5):430-437. DOI:10.1016/j.ijantimicag.2003.10.010
[2] Bravo FJ, et al. Effect of maternal treatment with cyclic HPMPC in the guinea pig model of congenital cytomegalovirus infection. J Infect Dis. 2006;193(4):591-597. DOI:10.1086/499603 |
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