| Identification | Back Directory | [Name]
Epinastine hydrobromide | [CAS]
127786-29-2 | [Synonyms]
EPINASTIN HBR
Epinastine HBr
Epinastine-13C-d3 HBr
Epinastin hydrobromide
epinastine hydrobromide
9,13b-Dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine hydrobromide
9,13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3-amine monohydrobromide
(+/-)-3-amino-9,13b-dihydro-1h-dibenz[c,f]imidazo[1,5-a]azepine hydrobromide
6-Aminomethyl-6,11-dihydro-5H-dibenz[b,e]azepine (E)-2-butenedioate Epinastine hydrobromide | [EINECS(EC#)]
821-693-3 | [Molecular Formula]
C16H16BrN3 | [MOL File]
127786-29-2.mol | [Molecular Weight]
330.222 |
| Chemical Properties | Back Directory | [Melting point ]
284-286° | [storage temp. ]
Sealed in dry,Room Temperature | [InChI]
InChI=1S/C16H15N3.BrH/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16;/h1-8,15H,9-10H2,(H2,17,18);1H | [InChIKey]
ADPMHRDERZTFIN-UHFFFAOYSA-N | [SMILES]
N12C(N)=NCC1C1C=CC=CC=1CC1C=CC=CC2=1.Br |
| Questions And Answer | Back Directory | [Application]
Clinical studies have shown that, at the same dosage, epinastine hydrochloride is significantly more effective than other second-generation histamine H1 receptor antagonists such as terfenadine, astamiva, and ketotifen, and also has a lower incidence of central sedation and cardiotoxicity. Therefore, the market demand for epinastine hydrochloride is substantial, making its synthesis necessary. Literature searches reveal that publicly available patents and literature use 6-aminomethyl-6,11-dihydro-5H-dibenzo[b,e]azapyridine (Ⅳ) as a key intermediate in epinastine synthesis, which is cyclized with cyanogen bromide to yield epinastine. Epinastine hydrobromide is also a synthetic intermediate for epinastine. |
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