| Identification | Back Directory | [Name]
CP 93129 DIHYDROCHLORIDE | [CAS]
127792-75-0 | [Synonyms]
CP-93129
CP931292HCl
CP 93129 DIHYDROCHLORIDE
3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one
3-(1,2,3,6-Tetrahydropyridine-4-yl)-1,4-diaza-1H-indene-5(4H)-one
3-[(1,2,3,6-Tetrahydropyridin)-4-yl]-1H-pyrrolo[3,2-b]pyridin-5(4H)-one
3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1,4-dihydro-pyrrolo[3,2-b]pyridin-5-one
1,4-dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrol[3,2-b]pyridin-5-one
1,4-Dihydro-3-(1,2,3,6-tetrahydropyridine-4-yl)-5H-pyrrolo[3,2-b]pyridine-5-one
1,4-DIHYDRO-3-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-5H-PYRROL[3,2-B]PYRIDIN-5-ONE DIHYDROCHLORIDE
1,4-Dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrolo[3,2-b]pyridin-5-one dihydrochloride | [Molecular Formula]
C12H13N3O | [MDL Number]
MFCD01862675 | [MOL File]
127792-75-0.mol | [Molecular Weight]
215.25 |
| Chemical Properties | Back Directory | [Melting point ]
248 °C | [Boiling point ]
531.5±50.0 °C(Predicted) | [density ]
1.274±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at RT | [solubility ]
Methanol: Slightly soluble: 0.1-1 mg/ml | [pka]
13.42±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
CP 93129 dihydrochloride is a 5HT1B agonist. | [Definition]
ChEBI: 3-(1,2,3,6-tetrahydropyridin-4-yl)-1,4-dihydropyrrolo[3,2-b]pyridin-5-one is a pyrrolopyridine. | [Biological Activity]
Potent and highly selective 5-HT 1B agonist. | [IC 50]
5-HT1B Receptor | [References]
[1] DR. B. KENNETH KOE. Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253[J]. Drug Development Research, 1992, 26 3: 241-250. DOI: 10.1002/ddr.430260305
[2] ANITA CHADHA. The 5HT1B receptor agonist, CP-93129, inhibits [3H]-GABA release from rat globus pallidus slices and reverses akinesia following intrapallidal injection in the reserpine-treated rat[J]. British Journal of Pharmacology, 2009, 130 8: 1927-1932. DOI: 10.1038/sj.bjp.0703526
[3] M D LEE. Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats.[J]. Psychopharmacology, 1998, 136 3: 304-307. DOI: 10.1007/s002130050570
[4] MAKOTO BANNAI. Anti-aggressive effects of agonists at 5-HT1B receptors in the dorsal raphe nucleus of mice.[J]. Psychopharmacology, 2007, 193 2: 295-304. DOI: 10.1007/s00213-007-0780-5 |
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