| Identification | Back Directory | [Name]
1-N-Boc-2-Methylhydrazine | [CAS]
127799-54-6 | [Synonyms]
1-Boc-2-methylhydrazine
1-N-Boc-2-Methylhydrazine
tert-butyl N-(methylamino)carbamate
tert-butyl 2-Methylhydrazinecarboxylate
1-(t-butyloxy)carbonyl-2-Methylhydrazine
1-(t-butylo×y)carbonyl-2-Methylhydrazine
tert-butyl 2-methylhydrazine-1-carboxylate
2-Methylhydrazinecarboxylic acid tert-butyl est
2-Methylhydrazinecarboxylic acid tert-butyl ester
2-Methylhydrazinecarboxylic acid,1,1-dimethylethyl ester
Hydrazinecarboxylic acid, 2-Methyl-, 1,1-diMethylethyl ester | [Molecular Formula]
C6H14N2O2 | [MDL Number]
MFCD16660139 | [MOL File]
127799-54-6.mol | [Molecular Weight]
146.19 |
| Chemical Properties | Back Directory | [Melting point ]
49-51℃ | [density ]
0.982±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [pka]
10.73±0.43(Predicted) | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C6H14N2O2/c1-6(2,3)10-5(9)8-7-4/h7H,1-4H3,(H,8,9) | [InChIKey]
UZRUVUYVHGPEAP-UHFFFAOYSA-N | [SMILES]
N(C(OC(C)(C)C)=O)NC |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 1-Boc-2-methylhydrazine from 1-Cbz-2-Boc-1-methylhydrazine is as follows: 24.8 g (70.8 mmol) of 1-benzyl-2-tert-butyl-1-methylhydrazine-1,2-dicarboxylate was dissolved in 500 mL of ethanol at room temperature and standard atmospheric pressure, and 1.24 g of palladium (10% activated charcoal) was added as a catalyst for the hydrogenation reaction. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth to remove the catalyst and the filtrate was concentrated and dried under reduced pressure to give the product. The yield was 12.3 g with a purity of 48%, representing 57% of the theoretical yield. | [References]
[1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 16, p. 2297 - 2311
[2] Journal of the American Chemical Society, 1993, vol. 115, # 20, p. 8898 - 8906
[3] Tetrahedron Letters, 1996, vol. 37, # 2, p. 183 - 186
[4] Patent: US5030724, 1991, A
[5] Patent: US2016/52884, 2016, A1. Location in patent: Paragraph 0599-0600 |
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