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127882-73-9

127882-73-9 Structure

127882-73-9 Structure
IdentificationBack Directory
[Name]

AIDS058893
[CAS]

127882-73-9
[Synonyms]

W-68
AIDS058893
(5R)-5,5aα,8aβ,9-Tetrahydro-9α-[4-nitrophenylamino]-5β-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(8H)-one
(5R)-5β-(4-Hydroxy-3,5-dimethoxyphenyl)-9α-(4-nitrophenylamino)-5,5aα,6,8,8aβ,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-6-one
(5R)-5,8,8aβ,9-Tetrahydro-5β-(4-hydroxy-3,5-dimethoxyphenyl)-9α-[(4-nitrophenyl)amino]furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-6(5aαH)-one
Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[(4-nitrophenyl)amino]-, (5R,5aR,8aS,9S)-
(5R)-5β-(3,5-Dimethoxy-4-hydroxyphenyl)-7α-(hydroxymethyl)-8α-(4-nitrophenylamino)-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole-6β-carboxylic acid 6,7-lactone
[Molecular Formula]

C27H24N2O9
[MOL File]

127882-73-9.mol
[Molecular Weight]

520.49
Chemical PropertiesBack Directory
[Melting point ]

206-207 °C(Solv: ethyl acetate (141-78-6))
[Boiling point ]

751.5±60.0 °C(Predicted)
[density ]

1.459±0.06 g/cm3(Predicted)
[pka]

9.94±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

GL-331 is a potent anti-cancer agent. GL-331 has demonstrated more efficacious anti-cancer activity in both the in vitro and in vivo lymphoma systems[1].
[References]

[1] You Y. Podophyllotoxin derivatives: current synthetic approaches for new anticancer agents. Curr Pharm Des. 2005;11(13):1695-717. DOI:10.2174/1381612053764724
[2] Huang TS, et al. A novel podophyllotoxin-derived compound GL331 is more potent than its congener VP-16 in killing refractory cancer cells. Pharm Res. 1999 Jul;16(7):997-1002. DOI:10.1023/a:1018971313256
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