| Identification | Back Directory | [Name]
1-BENZYL-1,7-DIAZASPIRO[4,4]NONANE | [CAS]
128244-01-9 | [Synonyms]
1-BENZYL-1,7-DIAZASPIRO[4,4]NONANE
1,7-Diazaspiro[4.4]nonane, 1-(phenylMethyl)-
1-Benzyl-1,7-diazaspiro[4.4]nonane heMioxalte
1-Benzyl-1,7-diazaspiro[4.4]nonane hemioxalate, 95% | [Molecular Formula]
C14H20N2 | [MDL Number]
MFCD09056754 | [MOL File]
128244-01-9.mol | [Molecular Weight]
216.32 |
| Chemical Properties | Back Directory | [Boiling point ]
328.1±17.0 °C(Predicted) | [density ]
1.08±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
10.68±0.20(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
The synthesis of the 1-benzyl-1,7-diazaspiro[4,4]nonane core structure (a spirocyclic diamine structure) typically involves a multi-step reaction to construct two fused pyrrolidine rings sharing a single spirocyclic carbon atom. A common approach is to utilize suitable linear or pre-cyclized precursors for reductive amination or cyclization. For example, the synthesis can begin with a protected diamine derivative followed by a key step, such as an intramolecular cyclization of a linear intermediate containing a primary amine and an electrophilic center (e.g., a toluenesulfonate or halide), to form one of the pyrrolidine rings. The second ring forms the spirocyclic center, typically constructed via a subsequent cyclization reaction or a [3+2] cycloaddition reaction. The final step is the introduction of a benzyl group, usually through N-alkylation of the secondary amine with benzyl bromide or benzyl chloride, or reductive amination with benzaldehyde, followed by removal of the remaining protecting group to yield 1-benzyl-1,7-diazaspiro[4.4]nonane. |
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Energy Chemical
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