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128496-10-6

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128496-10-6 Structure

128496-10-6 Structure
IdentificationBack Directory
[Name]

3',5'-Bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinouridine
[CAS]

128496-10-6
[Synonyms]

3’,5’-Bis-O-benzoyl-2’-deoxy-2’-fluoro-β-D-arabinouridine
3’,5’-Bis-O-benzoyl-2’-deoxy-2’-fluoro-b-D-arabinouridine
3',5'-Bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinouridine
1-(3',5'-Di-O-benzoyl-2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)uracil
2,4(1H,3H)-Pyrimidinedione, 1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
2,4(1H,3H)-PyriMidinedione, 1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-b-D-arabinofuranosyl)-
1-(3,5-Di-O-benzoyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione
(2R,3R,4S,5R)-2-[(BENZOYLOXY)METHYL]-5-(2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-1-YL)-4-FLUOROOXOLAN-3-YL BENZOATE
((2R,3R,4S,5R)-3-(Benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-2-yl)methyl benzoate
[Molecular Formula]

C23H19FN2O7
[MOL File]

128496-10-6.mol
[Molecular Weight]

454.4
Chemical PropertiesBack Directory
[Melting point ]

185-187 °C(Solv: chloroform (67-66-3); methanol (67-56-1))
[density ]

1.45±0.1 g/cm3(Predicted)
[pka]

9.39±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

3’,5’-Bis-O-benzoyl-2’-deoxy-2’-fluoro-β-D-arabinouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
[References]

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
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