| Identification | Back Directory | [Name]
sauristolactam | [CAS]
128533-02-8 | [Synonyms]
Saurolactam
sauristolactam
Sauristolactam (Saurolactam)
Sauristolactam (Synonyms: Saurolactam)
Dibenz[cd,f]indol-4(5H)-one, 2-hydroxy-1-methoxy-5-methyl- | [Molecular Formula]
C17H13NO3 | [MDL Number]
MFCD31813703 | [MOL File]
128533-02-8.mol | [Molecular Weight]
279.29 |
| Hazard Information | Back Directory | [Uses]
Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus chinensis, has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells[1]. Sauristolactam also inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation[2]. | [References]
[1] Kim SR, et al. Aristolactam BII of Saururus chinensis attenuates glutamate-induced neurotoxicity in rat cortical cultures probably by inhibiting nitric oxide production. Planta Med. 2004 May;70(5):391-6. DOI:10.1055/s-2004-818964
[2] Li Z, et al. Saurolactam Inhibits Proliferation, Migration, and Invasion of Human Osteosarcoma Cells. Cell Biochem Biophys. 2015 Jul;72(3):719-26. DOI:10.1007/s12013-015-0523-x |
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