| Identification | Back Directory | [Name]
1H-Pyrazole-4-carboxylic acid, 1-[3-cyano-1-(1-methylethyl)-1H-indol-5-yl]- | [CAS]
1287766-55-5 | [Synonyms]
Tigulixostat
1H-Pyrazole-4-carboxylic acid, 1-[3-cyano-1-(1-methylethyl)-1H-indol-5-yl]- | [Molecular Formula]
C16H14N4O2 | [MOL File]
1287766-55-5.mol | [Molecular Weight]
294.31 |
| Chemical Properties | Back Directory | [Boiling point ]
554.5±35.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
3.70±0.10(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
Tigulixostat (LC350189) is an orally active, non-purine selective xanthine oxidase inhibitor. Tigulixostat lowers the production of uric acid. Tigulixostat can be used for gout and hyperuricemia study[1][2][3]. | [References]
[1] Seonghae Yoon, et al. Pharmacokinetics, pharmacodynamics, and tolerability of LC350189, a novel xanthine oxidase inhibitor, in healthy subjects. Drug Des Devel Ther. 2015 Aug 31;9:5033-49. DOI:10.2147/DDDT.S86884
[2] Li X, et al. Pharmacological urate-lowering approaches in chronic kidney disease. Eur J Med Chem. 2019 Mar 15;166:186-196. DOI:10.1016/j.ejmech.2019.01.043
[3] Terkeltaub R, et al. Serum Urate-Lowering Efficacy and Safety of Tigulixostat in Gout Patients With Hyperuricemia: A Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Trial. Arthritis Rheumatol. 2023 Jul;75(7):1275-1284. DOI:10.1002/art.42447 |
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