| Identification | Back Directory | [Name]
SUC-ALA-GLU-PRO-PHE-PNA | [CAS]
128802-76-6 | [Synonyms]
Suc-AEPF-pNA
SUC-ALA-GLU-PRO-PHE-PNA
Suc-Ala-Glu-Pro-Phe-pNA≥ 98% (HPLC)
N-(3-Carboxy-1-oxopropyl)-L-alanyl-L-α-glutamyl-L-prolyl-N-(4-nitrophenyl)-L-phenylalaninamide
L-Phenylalaninamide, N-(3-carboxy-1-oxopropyl)-L-alanyl-L-α-glutamyl-L-prolyl-N-(4-nitrophenyl)- | [Molecular Formula]
C32H38N6O11 | [MDL Number]
MFCD00238367 | [MOL File]
128802-76-6.mol | [Molecular Weight]
682.68 |
| Chemical Properties | Back Directory | [Boiling point ]
1165.357±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.408±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
-15°C | [form ]
Solid | [pka]
4.474±0.10(predicted) | [color ]
White to off-white | [Sequence]
{Suc}-Ala-Glu-Pro-Phe-{pNA} |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc[1][2]. | [References]
[1] Subedi A, et al. Discovery of novel selenium derivatives as Pin1 inhibitors by high-throughput screening. Biochem Biophys Res Commun. 2016 Jun 3;474(3):528-533. DOI:10.1016/j.bbrc.2016.04.124
[2] Liu C, et al. Imazamethabenz inhibits human breast cancer cell proliferation, migration and invasion via combination with Pin1. Mol Med Rep. 2017 May;15(5):3210-3214. DOI:10.3892/mmr.2017.6399 |
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