| Hazard Information | Back Directory | [Description]
LDN-193665 is a potent tau kinase inhibitor. It acts by targeting CDK5?/p25 and GSK3β. | [Uses]
LDN-193665 is a Tau kinase inhibitor with tauopathy-modifying activity. LDN-193665 inhibits Tau phosphorylation, improves tauopathy in animal models, reduces Sarkosyl-insoluble Tau, and restores memory. It may be necessary to simultaneously target multiple kinases to effectively inhibit tauopathies. | [References]
[1] Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models DOI:10.1074/jbc.M112.436402 |
|
|