| Identification | Back Directory | [Name]
Ocaperidone | [CAS]
129029-23-8 | [Synonyms]
R79598
Ocaperidone
Ocaperidona
Ocaperidone (R79598)
Ocaperidone USP/EP/BP
3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2,9-dimethylpyrido[1,2-a]pyrimidin-4-one
3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2,9-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one
4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-2,9-dimethyl-
5-hydroxytryptamine Receptor,Ocaperidone,inhibit,Serotonin Receptor,R 79598,Inhibitor,Dopamine Receptor,5-HT Receptor,R-79598 | [Molecular Formula]
C24H25FN4O2 | [MDL Number]
MFCD00866668 | [MOL File]
129029-23-8.mol | [Molecular Weight]
420.486 |
| Chemical Properties | Back Directory | [Melting point ]
180.0 to 184.0 °C | [Boiling point ]
588.0±60.0 °C(Predicted) | [density ]
1.32 g/cm3 | [storage temp. ]
2-8°C | [solubility ]
DMSO:16.0(Max Conc. mg/mL);38.1(Max Conc. mM) | [form ]
powder to crystal | [pka]
7.97±0.10(Predicted) | [color ]
White to Light yellow | [CAS DataBase Reference]
129029-23-8 |
| Hazard Information | Back Directory | [Uses]
Antipsychotic. | [Definition]
ChEBI: Ocaperidone is a pyridopyrimidine. | [in vivo]
Ocaperidone shows a potent occupation of 5HT2 receptor via in vivo binding in the frontal cortex of rats with an ED50 of 0.04 mg/kg, and 0.1 4-0.1 6 mg/kg for D2 receptor in the striatum and the nucleus accumbens[1]. Ocaperidone (R 79598) antagonizes dopamine D2 and 5-HT2, and shows a a partial generalization to buspirone with an ED50 of 0.163 mg/kg[3]. | [IC 50]
5-HT2 Receptor: 0.14 nM (Ki); a1-adrenergic receptor: 0.46 nM (Ki); D2 Receptor: 0.75 nM (Ki); Histamine H1: 1.6 nM (Ki); a2-adrenergic receptor: 5.4 nM (Ki); 5-HT1A Receptor: 7.6 (pEC50, h5-HT1A); 5-HT1A Receptor: 8.08 (pKi, h5-HT1A) | [storage]
Store at -20°C |
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| Company Name: |
TCI AMERICA
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800-4238616 |
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https://www.tcichemicals.com/en/us/index.html |
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