129042-57-5

141-82-2

66-99-9

129042-57-5

The general procedure for the synthesis of 3-amino-3-(2-naphthalenyl)propionic acid from malonic acid and 2-naphthaldehyde was as follows: a mixture of 2.40 g of 2-naphthaldehyde (1-15 mmol), 2.44 g of malonic acid, and 3.54 g of ammonium acetate (molar ratio 1:1.1:2.3) was dissolved in 200 mL of 1-butanol, and the reaction was carried out at reflux for 1.5-2 hr, until the cessation of the release of carbon dioxide gas. Upon completion of the reaction, the precipitate formed was filtered and washed sequentially with boiling 1-butanol (2 x 50 mL), boiling ethanol (2 x 50 mL) and 100 mL of water. The precipitate was dried at 80-100°C for 8-10 hours. The purity of the product was checked by thin layer chromatography (TLC) and the reaction yield was about 65-80%.