| Identification | Back Directory | [Name]
N-(tert-Butoxycarbonal)-phenylalanyl-histidyl-(4-amino-3-hydroxy-5-cyc lohexyl)-pentacarbonyl-isoleucyl-(2-amidomethyl)tetrazol | [CAS]
129049-51-0 | [Synonyms]
EMD 52297
N-(tert-Butoxycarbonal)-phenylalanyl-histidyl-(4-amino-3-hydroxy-5-cyc lohexyl)-pentacarbonyl-isoleucyl-(2-amidomethyl)tetrazol
L-threo-Pentonamide, 5-cyclohexyl-2,4,5-trideoxy-4-[[N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-L-histidyl]amino]-N-[2-methyl-1-[[(2H-tetrazol-2-ylmethyl)amino]carbonyl]butyl]-, [S-(R*,R*)]- (9CI) | [Molecular Formula]
C39H59N11O7 | [MOL File]
129049-51-0.mol | [Molecular Weight]
793.96 |
| Hazard Information | Back Directory | [Description]
Emd 52297 is a renin inhibitor. | [Uses]
EMD 52297 is a Renin inhibitor, with acute hemodynamic and hormonal effects. EMD 52297 also acts as an ACE inhibitor[1][2]. | [References]
[1] Miriam T Rademaker, et al. Hemodynamic, hormonal, and renal effects of (pro)renin receptor blockade in experimental heart failure. Circ Heart Fail. 2012 Sep 1;5(5):645-52. DOI:10.1161/CIRCHEARTFAILURE.112.967059
[2] Jürgen Maibaum, et al. Renin inhibitors as novel treatments for cardiovascular disease. Expert Opinion on Therapeutic Patents. Volume 13, 2003 - Issue 5. |
|
| Company Name: |
CHEMICAL LAND21
|
| Tel: |
82- 2 -783 - 8063 |
| Website: |
www.chemicalland21.com |
|