| Identification | Back Directory | [Name]
Isoangustone A | [CAS]
129280-34-8 | [Synonyms]
Isoangustone A
3-[3,4-Dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-4H-chromen-4-one
3-[3,4-Dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 3-[3,4-dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)- | [Molecular Formula]
C25H26O6 | [MOL File]
129280-34-8.mol | [Molecular Weight]
422.47 |
| Hazard Information | Back Directory | [Uses]
Isoangustone A is a secondary metabolite of Licorice. Isoangustone A was shown to suppress the proliferation of human melanoma cells and induce apoptosis in colorectal cancer cells. | [Definition]
ChEBI: Isoangustone A is a member of isoflavanones. | [in vivo]
Isoangustone A (2 or 10 mg/kg; i.p.; daily for 35 days) significantly decreases tumor growth, volume, and weight of SK-MEL-28 xenografts in mice[1]. | Animal Model: | Male Balb/c nu/nu mice, SK-MEL-28 xenograft model[1] | | Dosage: | 2 or 10 mg/kg | | Administration: | Intraperitoneal injection, daily for 35 days | | Result: | Significantly suppressed tumor weight compared to the control group. Markedly inhibited the expression of proliferating cell nuclear antigen (PCNA). Decreased phosphorylation levels of Akt. |
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