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1295298-26-8

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1295298-26-8 Structure

1295298-26-8 Structure
IdentificationBack Directory
[Name]

CCR1 antagonist 8
[CAS]

1295298-26-8
[Synonyms]

CCR1 antagonist 8
CCR1 antagonist 8,CCR-1 antagonist 8
1H-Pyrazolo[3,4-c]pyridine-4-carboxamide, 1-(4-fluorophenyl)-N-[1-[2-(methylsulfonyl)-4-pyridinyl]cyclopropyl]-
[Molecular Formula]

C22H18FN5O3S
[MDL Number]

MFCD31813719
[MOL File]

1295298-26-8.mol
[Molecular Weight]

451.47
Chemical PropertiesBack Directory
[Boiling point ]

729.2±60.0 °C(Predicted)
[density ]

1.51±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

10.35±0.20(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

BI 639667 (compound 19n), a third azaindazole series compound, is a CCR1 antagonist, with an IC50 of 1.8 nM in Ca2+ flux assay[1].
[IC 50]

CCR1: 1.8 nM (IC50, in Ca2+ flux assay)
[References]

[1] Harcken C, et al. Identification of novel azaindazole CCR1 antagonist clinical candidates. Bioorg Med Chem Lett. 2019 Feb 1;29(3):441-448. DOI:10.1016/j.bmcl.2018.12.024
Spectrum DetailBack Directory
[Spectrum Detail]

CCR1 antagonist 8(1295298-26-8)1HNMR
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