| Identification | Back Directory | [Name]
N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine | [CAS]
129639-79-8 | [Synonyms]
Abafungin
BAY-W 6341
4-(2-(2,4-dimethylphenoxy)phenyl)-N-(1,4,5,6-tetrahydropyrimidin-2-yl)thiazol-2-amine
N-[4-[2-(2,4-Dimethylphenoxy)phenyl]-2-thiazolyl]-1,4,5,6-tetrahydro-2-pyrimidinamine
2-Pyrimidinamine, N-[4-[2-(2,4-dimethylphenoxy)phenyl]-2-thiazolyl]-1,4,5,6-tetrahydro-
N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine | [Molecular Formula]
C21H22N4OS | [MDL Number]
MFCD00942263 | [MOL File]
129639-79-8.mol | [Molecular Weight]
378.49 |
| Chemical Properties | Back Directory | [Melting point ]
199 °C | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMF: 10 mg/mL; DMSO: 2.5 mg/mL; Ethanol: 0.3 mg/mL; PBS (pH 7.2): 0.3 mg/mL | [form ]
powder to crystal | [color ]
White to Light yellow | [InChI]
InChI=1S/C21H22N4OS/c1-14-8-9-18(15(2)12-14)26-19-7-4-3-6-16(19)17-13-27-21(24-17)25-20-22-10-5-11-23-20/h3-4,6-9,12-13H,5,10-11H2,1-2H3,(H2,22,23,24,25) | [InChIKey]
TYBHXIFFPVFXQW-UHFFFAOYSA-N | [SMILES]
C1(NC2=NC(C3=CC=CC=C3OC3=CC=C(C)C=C3C)=CS2)NCCCN=1 |
| Hazard Information | Back Directory | [Originator]
Abafungin,York Pharma | [Uses]
Abafungin is a broad-spectrum antifungal agent. | [Definition]
ChEBI: A member of the class of guanidines that is tetrahydropyrimidin-2(1H)-imine in which the hydrogen of the imino group is replaced by a thiazol-2-yl group which in turn is substituted by a 2-(2,4-dimethylphenoxy)phenyl group at position 4
It has been used for the topical treatment of fungal nail infections. | [Manufacturing Process]
15.8 g (0.12 mole) N-(1,4,5,6-tetrahydropyrimidinyl)thiourea were added to
27.45 g (0.1 mole) 2-(2,4-dimethylphenoxy)phenacyl chloride in 100 ml
acetone and heated to reflux for 2 hours. On cooling the falling out product
was filtered off, washed with acetone and dried. N-[4-[2-(2,4-
Dimethylphenoxy)phenyl]-2-thiazolyl]-1,4,5,6-tetrahydro-2-pyrimidinamine
hydrochloride was prepared. Yield 91.4%; MP: 160°C.
20.72 g (0.05 mole) above product was stirred with 300 ml 1 N sodium
hydroxide for 30 minutes at room temperature. The insoluble product was
filtered off, washed and dried. Yield of N-[4-[2-(2,4-dimethylphenoxy)phenyl]-
2-thiazolyl]-1,4,5,6-tetrahydro-2-pyrimidinamine was 16.2 g (86%). MP:
191°-192°C. | [Therapeutic Function]
Antibacterial, Antifungal |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
TCI Europe
|
| Tel: |
320-37350700 |
| Website: |
https://www.tcichemicals.com/de/de/index.html |
| Company Name: |
TCI AMERICA
|
| Tel: |
800-4238616 |
| Website: |
https://www.tcichemicals.com/en/us/index.html |
|