| Identification | Back Directory | [Name]
Minalrestat | [CAS]
129688-50-2 | [Synonyms]
ARI509
ARI-509
WAYARI-509
WAY-ARI-509
Minalrestat
Unii-G44pe6qb31
2-(4-Bromo-2-fluorobenzyl)-6-fluoro-1H-spiro[isoquinoline-4,3'-pyrrolidine]-1,2',3,5'(2H)-tetraone
Spiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone, 2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro- | [Molecular Formula]
C19H11BrF2N2O4 | [MDL Number]
MFCD00892338 | [MOL File]
129688-50-2.mol | [Molecular Weight]
449.206 |
| Hazard Information | Back Directory | [Uses]
Inhibitor(aldose reductase). | [Definition]
ChEBI:Minalrestat is a member of isoquinolines. | [in vivo]
Minalrestat (Oral gavage, 10 mg/kg/day, for 30 days) corrects the decreased microvascular reactivity in diabetic rats[1].
Minalrestat (Oral gavage, 10 mg/kg) restores the reduced number of leukocytes adhered and migrated leukocytes in postcapillary venules in diabetic rats[2].
| Animal Model: | Alloxan (40 mg/kg i.v.)-induced diabetic rats[1] | | Dosage: | 10 mg/kg/day | | Administration: | Oral gavage, for 30 days. | | Result: | Restored the decreased microvascular reactivity. |
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Leancare Ltd.
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| Tel: |
+33 962096793 |
| Website: |
www.leancare.co.uk |
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