| Identification | Back Directory | [Name]
2',4'-Dihydroxy-3',6'-dimethoxychalcone | [CAS]
129724-43-2 | [Synonyms]
4'-Dihydroxy-3'
6'-dimethoxychalcone
2',4'-DIHYDROXY-3',6'-DIMETHOXYC
1-(2,4-Dihydroxy-3,6-diMethoxyphenyl)-3-phenylprop-2-en-1-one
(2E)-1-(2,4-Dihydroxy-3,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one
2-Propen-1-one, 1-(2,4-dihydroxy-3,6-dimethoxyphenyl)-3-phenyl-, (2E)- | [Molecular Formula]
C17H16O5 | [MOL File]
129724-43-2.mol | [Molecular Weight]
300.31 |
| Chemical Properties | Back Directory | [Melting point ]
210 °C | [Boiling point ]
556.005±50.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.280±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
6.981±0.45(predicted) |
| Hazard Information | Back Directory | [Uses]
2',4'-Dihydroxy-3',6'-dimethoxychalcone is a natural product that can be isolated from Polygonum Lapathifolium. 2',4'-Dihydroxy-3',6'-dimethoxychalcone inhibits the growth of CCRF-CEM leukaemia cells and CEM/ADR5000 cells, with IC50 values of 10.67 and 18.60 μM, respectively[1][2]. | [References]
[1] Ahmed M, et al. Isoflavan-4-ol, dihydrochalcone and chalcone derivatives from Polygonum Lapathifolium. Phytochemistry, 1990, 29(6):2009-2011.
[2] Nkuété AH, et al. Anti-leukemia activity of semi-synthetic phenolic derivatives from Polygonum limbatum Meisn. Chem Cent J. 2015 Jun 24;9:40. DOI:10.1186/s13065-015-0115-2 |
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