| Identification | Back Directory | [Name]
CAY10654 | [CAS]
1298023-69-4 | [Synonyms]
CAY10654
CAY10654 Exclusive
N'-(5-chloro-2-hydroxyphenyl)-N-octylpropanediamide | [Molecular Formula]
C17H25ClN2O3 | [MOL File]
1298023-69-4.mol | [Molecular Weight]
340.85 |
| Chemical Properties | Back Directory | [Boiling point ]
568.5±50.0 °C(Predicted) | [density ]
1.186±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml | [form ]
A crystalline solid | [pka]
7?+-.0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
The gram-negative pathogen Pseudomonas aeruginosa uses N-acylated-L-homoserine lactones (AHLs) in quorum sensing to modulate transcriptional activators, including LasR, and regulate the expression of virulence factors. The same AHLs suppress the host immune system. CAY10654 is a synthetic analog of natural AHLs that suppresses host immunity without inducing LasR.1 It inhibits the proliferation of mouse peripheral blood leukocytes by concanavalin A (EC50 = 9.3 μM) without concurrent cytotoxicity.1 LasR is not induced by 100 μM CAY10654, although LasR is potently induced by natural AHL (5 μM) in positive control experiments.1 | [Uses]
N'-(5-Chloro-2-hydroxyphenyl)-N-octylpropanediamide is an organic compound[1]. | [Definition]
ChEBI: CAY10654 is an anilide. | [storage]
Store at -20°C | [References]
1. Jadhav, G.P., Chhabra, S.R., Telford, G., et al. Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone J. Med. Chem. 54(9),3348-3359(2011). |
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