| Identification | Back Directory | [Name]
1-O-(15-carboxypentadecyl)-2-O-acetylglycero-3-phosphorylcholine | [CAS]
129879-41-0 | [Synonyms]
PAF C-16 Carboxylic Acid
PKDXOBRCEXMRQQ-RUZDIDTESA-N
1-O-(15-carboxypentadecyl)-2-O-acetylglycero-3-phosphorylcholine | [Molecular Formula]
C26H52NO9P | [MOL File]
129879-41-0.mol | [Molecular Weight]
553.666 |
| Hazard Information | Back Directory | [Description]
PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the “remodeling” and ''de novo'' pathways. It is a potent mediator of neutrophil migration and the production of reactive oxygen species and IL-6. Pathological processes involving PAF include necrotizing enterocolitis, inflammation, asthma, and allergy. PAF C-16 Carboxylic acid is modified with a carboxylic acid group terminating the C-16 alkyl chain. This provides a convenient site for chemical crosslinking. | [Uses]
PAF C-16 carboxylic acid (Acetyl-CPGPC) is a phospholipid that possesses haptenic activity causing production of antibodies reactive with platelet-activating factor (PAF)[1]. | [References]
[1] K Karasawa, et al. Antibodies to synthetic platelet-activating factor (1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine) analogues with substituents at the sn-2 position. J Biochem. 1991 Nov;110(5):683-7. DOI:10.1093/oxfordjournals.jbchem.a123641 |
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