| Identification | Back Directory | [Name]
SDZ 280 446 | [CAS]
129893-84-1 | [Synonyms]
446
Sdz 280
SDZ 280 446
Cyclo[N-methyl-L-α-aspartyl-N-methyl-L-isoleucyl-N-methyl-L-isoleucylglycyl-N-methyl-L-valyl-O-methyl-L-tyrosyl-(2S)-2-hydroxypropanoyl-(2S)-2-piperidinecarbonyl-N-methyl-L-valyl-L-valyl], 1,1-dimethylethyl ester | [Molecular Formula]
C61H99N9O14 | [MDL Number]
MFCD00907201 | [MOL File]
129893-84-1.mol | [Molecular Weight]
1182.49 |
| Chemical Properties | Back Directory | [Melting point ]
146-148 °C | [Boiling point ]
1262.0±65.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [pka]
12.73±0.70(Predicted) | [Sequence]
cyclo-[Pec-MeVal-Val-(-O-t.Bu-MeAsp)-Melle-Melle-Gly7-MeVal-(O-MeTyr)-Hpa |
| Hazard Information | Back Directory | [Uses]
SDZ 280-446 is an orally active semisynthetic cyclic peptide lactone. SDZ 280-446 can be used in anticancer research[1]. | [References]
[1] Loor F, et al. SDZ 280-446, a novel semi-synthetic cyclopeptolide: in vitro and in vivo circumvention of the P-glycoprotein-mediated tumour cell multidrug resistance. Br J Cancer. 1992 Jan;65(1):11-8. DOI:10.1038/bjc.1992.3 |
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