| Identification | Back Directory | [Name]
kapurimycin A3 | [CAS]
129966-45-6 | [Synonyms]
Kafamycin
Kaphamycin
Caphamycin
kapurimycin A3
8-Acetyloxy-8,9,10,11-tetrahydro-12-hydroxy-2-[2-methyl-3-[(Z)-1-propenyl]oxiran-2-yl]-4,11-dioxo-4H-anthra[1,2-b]pyran-5-acetic acid
4H-Anthra[1,2-b]pyran-5-acetic acid, 8-(acetyloxy)-8,9,10,11-tetrahydro-12-hydroxy-2-[(2S,3R)-2-methyl-3-[(1Z)-1-propenyl]oxiranyl]-4,11-dioxo-, (8S)- (9CI) | [Molecular Formula]
C27H24O9 | [MDL Number]
MFCD01716630 | [MOL File]
129966-45-6.mol | [Molecular Weight]
492.47 |
| Chemical Properties | Back Directory | [Boiling point ]
736.472±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.491±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
3.512±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
Kapurimycin A3 is an antitumor and antibacterial antibiotic. Kapurimycin A3 has DNA binding and breakage activity. Kapurimycin A3 can be isolated from Streptomyces[1][2]. | [References]
[1] Hara M, et al. Covalent modification and single-strand scission of DNA by a new antitumor antibiotic kapurimycin A3. Biochemistry. 1990 Nov 20;29(46):10449-55. DOI:10.1021/bi00498a003
[2] PRODUCING ORGANISM, et al. THE KAPURIMYCINS, NEW ANTITUMOR ANTIBIOTICS PRODUCED BY STREPTOMYCES. The Journal of Antibiotics. 1990. 43 (12), p. 1513-1518 |
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