| Identification | Back Directory | [Name]
CARBOMETHOXYCARBONYL-PRO-PHE-OBZL | [CAS]
129987-97-9 | [Synonyms]
B1F
FTF
CPF
LRH1
B1F2
LRH-1
hB1F-2
FTZ-F1beta
LRH-1 human
LRH-1, GST tagged human
CARBOMETHOXYCARBONYL-PRO-PHE-OBZL
N-CARBOMETHOXYCARBONYL-PRO-PHE BENZYL ESTER
N-carbomethoxycarbonyl-prolyl-phenylalanyl-benzyl ester
L-Phenylalanine, 1-(methoxyoxoacetyl)-L-prolyl-, phenylmethyl ester (9CI)
(S)-Benzyl 2-((S)-1-(2-Methoxy-2-oxoacetyl)pyrrolidine-2-carboxaMido)-3-phenylpropanoate
benzyl (2S)-2-[[(2S)-1-(2-methoxy-2-oxoacetyl)pyrrolidine-2-carbonyl]amino]-3-phenylpropanoate | [Molecular Formula]
C24H26N2O6 | [MDL Number]
MFCD00153524 | [MOL File]
129987-97-9.mol | [Molecular Weight]
438.47 |
| Hazard Information | Back Directory | [Biological Activity]
LRH-1 or HB1F for human B1-binding factor belongs to the fushi tarazu factor-1 (FTZ-F1) subfamily of orphan nuclear receptors and is closely related to steroidogenic factor-1. LRH1 contains a DNA-binding domain with 2 zinc finger motifsan FTZ-F1 boxand a ligand-binding domain. Cholesterol 7-α-hydroxylase is the first and rate-limiting enzyme in a pathway through which cholesterol is metabolized to bile acids. Elevated promoter-specific repressor protein (SHP) inactivates LRH1 by forming a heterodimeric complex th at leads to promoter-specific repression of both CYP7A1 and SHP. These results revealed an elaborate autoregulatory cascade mediated by nuclear receptors for the maintenance of hepatic cholesterol catabolism. LRH1 specifically binds and activates viral hepatitis B enhancer IIan essential element for the liver-specific regulation of hepatitis B virus gene expression. CPF is a key regulator of human CYP7A gene expression in the liver. SHP1 represses expression of CYP7A |
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SynAsst Chemical.
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| Company Name: |
Nextpeptide Inc
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http://www.nextpeptide.com/ |
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