| Identification | Back Directory | [Name]
NQ301 | [CAS]
130089-98-4 | [Synonyms]
NQ301
NQ 301; NQ-301
NQ301 >=98% (HPLC)
NQ301 - Compound 211
2-(4-Acetylanilino)-3-chloronaphthalene-1,4-dione
2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione
2-((4-acetylphenyl)amino)-3-chloronaphthalene-1,4-dione
1,4-Naphthalenedione, 2-[(4-acetylphenyl)amino]-3-chloro- | [Molecular Formula]
C18H12ClNO3 | [MDL Number]
MFCD00559986 | [MOL File]
130089-98-4.mol | [Molecular Weight]
325.75 |
| Chemical Properties | Back Directory | [Melting point ]
241-243 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
476.8±45.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO:10.0(Max Conc. mg/mL);30.7(Max Conc. mM) | [form ]
powder | [pka]
-5.25±0.20(Predicted) | [color ]
faint red to dark red | [InChI]
1S/C18H12ClNO3/c1-10(21)11-6-8-12(9-7-11)20-16-15(19)17(22)13-4-2-3-5-14(13)18(16)23/h2-9,20H,1H3 | [InChIKey]
LSQZKIQSQHZVQS-UHFFFAOYSA-N | [SMILES]
O=C1C(Cl)=C(NC2=CC=C(C(C)=O)C=C2)C(C3=CC=CC=C31)=O |
| Hazard Information | Back Directory | [Uses]
NQ 301 possess antiplatelet effect, making it an antithrombotic agent. It significantly inhibited the collagen-?, thrombin-?, arachidonic acid-?, thapsigargin- and calcium ionophore A23187-?induced aggregation of washed human platelets. | [Biochem/physiol Actions]
NQ301 is an antithrombotic agent. Recent study shows that NQ301 (Compound 211) is a highly potent, selective, non-competitive allosteric inhibitor of CD45 that selectively inhibits dephosphorylation of substrate Lck pY-505 versus Lck pY-393. NQ301 prevents T cell receptor-mediated activation of Lck, Zap-70 and MAPK, and IL-2 production in primary T-cells. NQ301 exhibits immunosuppressive activity in mice. |
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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