| Hazard Information | Back Directory | [Description]
OMDM169 is a potent and selective MAGL inhibitor. OMDM169 is capable of enhancing 2-AG levels and of exerting analgesic activity via indirect activation of cannabinoid receptors. OMDM169 exhibited 0.13 microM10 microM) at human CB(1) and CB(2) receptors. OMDM69 might represent a template for the development of selective and even more potent inhibitors of 2-AG hydrolysis. | [Uses]
OMDM169 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor with activity to increase 2-AG levels. OMDM169 exerts analgesic activity through indirect activation of cannabinoid receptors. The effective concentration of OMDM169 is 0.13 μM[1]. | [References]
[1] The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG DOI:10.1038/cddis.2013.387 |
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