ChemicalBook--->CAS DataBase List--->130306-02-4

130306-02-4

130306-02-4 Structure

130306-02-4 Structure
IdentificationBack Directory
[Name]

(E)-2'-DEOXY-2'-(FLUOROMETHYLENE) CYTIDINE
[CAS]

130306-02-4
[Synonyms]

tezaciabine
(E)-2'-DEOXY-2'-(FLUOROMETHYLENE) CYTIDINE
Cytidine, 2'-deoxy-2'-(fluoromethylene)-, (2'E)-
[Molecular Formula]

C10H12FN3O4
[MDL Number]

MFCD00893181
[MOL File]

130306-02-4.mol
[Molecular Weight]

257.22
Chemical PropertiesBack Directory
[Boiling point ]

512.5±60.0 °C(Predicted)
[density ]

1.71±0.1 g/cm3(Predicted)
[storage temp. ]

-80°C
[solubility ]

DMSO : 200 mg/mL (777.54 mM; Need ultrasonic)
[form ]

Solid
[pka]

12.50±0.60(Predicted)
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

Tezacitabine is used in the synthesis of inhibitors of ribonucleoside diphosphate reductase.
[in vivo]

Tezacitabine (100 mg/kg; intraperitoneal injection; daily; female nude mice) treatment inhibits tumor growth in HCT 116 tumor xenografts[2].

Animal Model:Female nude mice (7-9-week-old) injected with HCT 116 cells[2]
Dosage:100 mg/kg
Administration:Intraperitoneal injection; daily; 14 days
Result:Inhibited tumor growth in HCT 116 tumor xenografts.
[storage]

-80°C
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