| Identification | Back Directory | [Name]
1-(4-BROMO-PHENYL)-4-METHYL-PIPERAZINE | [CAS]
130307-08-3 | [Synonyms]
1-(4-BROMO-PHENYL)-4-METHYL-PIPERAZINE
Piperazine, 1-(4-bromophenyl)-4-methyl-
1-bromo-4-(4-methyl-1-piperazinyl)benzene | [Molecular Formula]
C11H15BrN2 | [MDL Number]
MFCD09029689 | [MOL File]
130307-08-3.mol | [Molecular Weight]
255.15 |
| Chemical Properties | Back Directory | [Boiling point ]
331.0±37.0 °C(Predicted) | [density ]
1.350±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [pka]
7.71±0.42(Predicted) | [Appearance]
Off-white to yellow Solid | [InChI]
InChI=1S/C11H15BrN2/c1-13-6-8-14(9-7-13)11-4-2-10(12)3-5-11/h2-5H,6-9H2,1H3 | [InChIKey]
WCOODAWUEIXTFL-UHFFFAOYSA-N | [SMILES]
N1(C2=CC=C(Br)C=C2)CCN(C)CC1 |
| Hazard Information | Back Directory | [Synthesis]
Procedure for the synthesis of 1-(4-bromophenyl)-4-methylpiperazine (PZ959-2): 4-bromostyrene (PZ959-1, 22 g, 0.13 mol), 2-chloro-N-(2-chloroethyl)-N-methylethylamine (25.9 g, 0.17 mol), and triethylamine (353.5 mL, 0.38 mol) were dissolved in ethanol (300 mL). The reaction was refluxed for 80 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure, and the obtained residue was purified by high efficiency rapid column chromatography (DCM:EtOH=10:1) to obtain the target product PZ959-2 (20.3 g, 61% yield). LC-MS showed that [M+H]+ m/z=255.1. | [References]
[1] Patent: WO2012/130299, 2012, A1. Location in patent: Page/Page column 149 |
|
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
NovoChemy Ltd.
|
| Telephone: |
86-(0)21-31261262 373522135 |
| Website: |
www.novochemy.com |
|