| Identification | Back Directory | [Name]
(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt | [CAS]
1303993-73-8 | [Synonyms]
CHPG Sodium salt
(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt | [Molecular Formula]
C8H7ClNNaO3 | [MDL Number]
MFCD11100366 | [MOL File]
1303993-73-8.mol | [Molecular Weight]
223.589 |
| Hazard Information | Back Directory | [Uses]
CHPG Sodium Salt (cas# 1303993-73-8) is a useful research chemical.Also, it is derived from 2-Chloro-5-hydroxybenzaldehyde (C368225), which is used as a reagent in the synthesis of p38 inhibitors which are used for the treatment of chronic obstructive pulmonary disease. It is also used in the preparation of halogenated analogs of L-meta-tyrosine which is a biodegradable herbicide. 2-Chloro-5-hydroxybenzaldehyde may also be used as a starting material in the synthesis of chlorinated phenylephrine. | [Biological Activity]
CHPG sodium salt is a selective mGluR5 agonist and attenuates SO2-induced oxidative stress and inflammation in BV2 microglia via the TSG-6/NF-κB pathway. It prevents traumatic brain injury (TBI) in vitro and in vivo through the ERK and Akt pathways. | [in vitro]
CHPG sodium salt (10-500 μM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO 2 derivatives treatment.
It protects BV2 cells against SO 2 -induced apoptosis.
It treatment alone increases the expression of TSG-6 in both mRNA and protein levels.
Cell Viability Assay | Cell Line: | BV2 microglial cells | | Concentration: | 10, 50, 100 and 500 μM | | Incubation Time: | 24 hours | | Result: | Increased the cell viability. | < p class="cpd-mod-vv-tit "> Apoptosis Analysis | Cell Line: | BV2 microglial cells | < /tr> | Concentration: | 0.5 mM | | Incubation Time: | 30 mins | | Result: | Protected BV2 cells against SO 2 -induced apoptosis. | Western Blot Analysis | Cell Line: | BV2 microglial cells | | Concentration: | 0.5 mM | | Incubation Time: | 30 mins | | Result: | Increased the expression of TSG-6 in both mRNA and protein levels. | | [in vivo]
CHPG sodium salt (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume. | Animal Model: | Adult Sprague-Dawley male rats weighing 280-320 g | | Dosage: | 250 nM < /td> | | Administration: | Injection; for 7 days | < td class="col1 fwb"> Result: | Reduced significantly cerebral lesion volume. | | [target]
| [storage]
Store at RT |
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BOC Sciences
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R&D Systems, Inc
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