| Identification | Back Directory | [Name]
L-655,708 | [CAS]
130477-52-0 | [Synonyms]
MSD
L-655,708
ETHYL (S)-11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLATE
Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate
11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1.5-a]pyrrolo[2.1-c][1.4]benzodiazepine-1-carboxylicacidethylester
(S)-ethyl 7-methoxy-9-oxo-11,12,13,13a-
tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a][1,4]diazepine-1-carboxylate
11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLIC ACID, ETHYL ESTER
9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)-
9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)- (011-14426_500Mg) | [Molecular Formula]
C18H19N3O4 | [MDL Number]
MFCD02684528 | [MOL File]
130477-52-0.mol | [Molecular Weight]
341.36 |
| Chemical Properties | Back Directory | [Melting point ]
175-176 °C | [Boiling point ]
584.4±50.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at +4°C | [solubility ]
DMSO: 6 mg/mL
| [form ]
powder
| [pka]
1.49±0.20(Predicted) | [color ]
White to yellow | [InChI]
1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1 | [InChIKey]
YKYOQIXTECBVBB-AWEZNQCLSA-N | [SMILES]
CCOC(=O)c1ncn2-c3ccc(OC)cc3C(=O)N4CCCC4c12 |
| Hazard Information | Back Directory | [Uses]
L-655,708 has been used as an α5 GABAA receptor inverse agonist to inhibit the discriminative stimulus of propofol in a dose-dependent manner. | [Biological Activity]
Potent, selective inverse agonist for the benzodiazepine site of GABA A receptors containing the α 5 subunit (K i = 0.45 nM). Displays 50-100-fold selectivity over GABA A receptors containing α 1, α 2, α 3 or α 6 subunits in combination with β 3 and γ 2. Enhances LTP in? a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity. | [Biochem/physiol Actions]
L-655,708 is an inverse agonist of the α5 γ-Aminobutyric acid type A (GABAA) receptor. It has an ability to increase cognition in rats. | [in vivo]
L-655708 at 0.7 mg/kg, administered intraperitoneally, would result in 60-70% occupancy of α5 GABAA receptors with limited binding to α1, α2, and α3 subunit-containing GABAA receptors and no significant off-target behavioral effects, such as sedation and motor impairment. | [storage]
Desiccate at +4°C |
|
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