| Identification | Back Directory | [Name]
bimoclomol | [CAS]
130493-03-7 | [Synonyms]
bimoclomol
3-Pyridinecarboximidoyl chloride, N-[2-hydroxy-3-(1-piperidinyl)propoxy]- | [Molecular Formula]
C14H20ClN3O2 | [MDL Number]
MFCD00932421 | [MOL File]
130493-03-7.mol | [Molecular Weight]
297.78 |
| Hazard Information | Back Directory | [Uses]
Bimoclomol is a heat shock protein (HSP) coinducer, used for treatment of cardiovascular diseases. | [in vivo]
Bimoclomol (1 and 5 mg/kg) decreases the ST-segment elevation induced by coronary occlusion by 56% and 80%, respectively, in anesthetized dogs[1]. | [IC 50]
HSP | [storage]
Store at -20°C | [References]
[1] Jednakovits A, et al. In vivo and in vitro acute cardiovascular effects of bimoclomol. Gen Pharmacol. 2000 May;34(5):363-9. DOI:10.1016/s0306-3623(01)00074-x
[2] Hargitai J, et al. Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1. Biochem Biophys Res Commun. 2003 Aug 1;307(3):689-95. DOI:10.1016/s0006-291x(03)01254-3
[3] Polakowski JS, et al. Bimoclomol elevates heat shock protein 70 and cytoprotects rat neonatal cardiomyocytes. Eur J Pharmacol. 2002 Jan 18;435(1):73-7. DOI:10.1016/s0014-2999(01)01551-5 |
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