| Identification | Back Directory | [Name]
EPLIVANSERIN FUMARATE | [CAS]
130580-02-8 | [Synonyms]
SR 46349B
SR-46349 Fumarate
EPLIVANSERIN FUMARATE
Eplivanserin hemifumarate
SR-46349 hemifumarate salt
Eplivanserin hemifumarate salt
SR-46349 hemifumarate salt >=98% (HPLC)
TRANS-2''-FLUORO-4-HYDROXYCHALCONE O-[(Z)-2-(DIMETHYLAMINO)ETHYL]OXIME--FUMARIC ACID (2:1)
4-((3Z)-3-(2-Dimethylaminoethyl)oxyimino-3-(2-fluorophenyl)propen-1-yl)phenol hemifumarate salt
(Z,E)-1-(2-Fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one O-[2-(dimethylamino)ethyl]oxime fumarate (2:1)
(1Z,2E)-1-(2-Fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one O-[2-(dimethylamino)ethyl]oxime hemifumarate | [Molecular Formula]
C23H25FN2O6 | [MDL Number]
MFCD00893361 | [MOL File]
130580-02-8.mol | [Molecular Weight]
444.46 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥10mg/mL | [form ]
powder | [color ]
white to off-white | [InChIKey]
RNLKLYQQDLHHBH-ABDBJYMXSA-N | [SMILES]
OC(=O)\C=C\C(O)=O.CN(C)CCO\N=C(\C=C\c1ccc(O)cc1)c2ccccc2F.CN(C)CCO\N=C(\C=C\c3ccc(O)cc3)c4ccccc4F |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,N | [Risk Statements ]
22-50 | [Safety Statements ]
61 | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
2 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1 |
| Hazard Information | Back Directory | [Uses]
Eplivanserin Hemifumarate is a 5-HT2A antagonist. | [Biological Activity]
SR-46349 is an antagonist of 5-HT (2A/2C) receptor and increases the release of dopamine by medial prefrontal cortex in rats.1 It increases the signal transduction induced by 5-HT2 receptor by binding with high affinity.2 SR-46349 inhibits the aggregation of rabbit and human platelets in response to serotonin.3''ASTAR (Antagonist of Serotonin 5HT2A Receptors). | [in vivo]
Eplivanserin hemifumarate (SR 46349B) inhibits 5-HT2 receptor binding of [3H]ketanserin with an ED50 of 0.087 mg/kg after i.p. injection, and 0.097 mg/kg after p.o administration in mice[1].
SR 46349B (0.25-1 mg/kg; i.p.) blocks Cocaine-evoked hyperactivity following repeated Cocaine treatment in rats[2]. | [IC 50]
5-HT2A Receptor: 5.8 nM (IC50); 5-HT2C Receptor: 120 nM (IC50) | [storage]
Store at +4°C |
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