| Identification | Back Directory | [Name]
LY-2940094 | [CAS]
1307245-87-9 | [Synonyms]
CS-2822
LY-2940094
LY-2940094 tartrate
LY-2940094 tartrate，BTRX-246040 | [Molecular Formula]
C26H29ClF2N4O8S | [MDL Number]
MFCD32633525 | [MOL File]
1307245-87-9.mol | [Molecular Weight]
631.04 |
| Hazard Information | Back Directory | [Uses]
LY2940094 (BTRX-246040) tartrate is a potent, brain penetrant, selective and orally available N/OFQ peptide (NOP) receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 tartrate reduces Ethanol self-administration and Ethanol seeking in animal models[1]. | [in vivo]
LY2940094 (3, 10, or 30 mg/kg; orally daily for 4 days) dose-dependently reduces homecage ethanol self-administration in Indiana Alcohol-Preferring (P) and Marchigian Sardinian Alcohol-Preferring (msP) rats, without affecting food/water intake or locomotor activity[1]. | Animal Model: | Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)[1] | | Dosage: | 3, 10, or 30 mg/kg | | Administration: | P.o.; daily for 4 days | | Result: | Reduced homecage ethanol self-administration.
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| [References]
[1] Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40(5):945-54. DOI:10.1111/acer.13052 |
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| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|