| Identification | Back Directory | [Name]
MDL-29951 | [CAS]
130798-51-5 | [Synonyms]
CS-1105
MDL-29951, >=98%
MDL-29951; MDL29951
2-Carboxy-4,6-dichloro-1H-indole-3-propionic acid
2-Carboxy-4,6-dichloro-1H-indole-3-propanoic acid
3-(2-carboxy-4,6-dichloroindol-3-yl)propionic acid
1H-Indole-3-propanoic acid, 2-carboxy-4,6-dichloro-
3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid
MDL-29951 2-Carboxy-4,6-dichloro-1H-indole-3-propanoic acid | [EINECS(EC#)]
200-256-5 | [Molecular Formula]
C12H9Cl2NO4 | [MDL Number]
MFCD00897722 | [MOL File]
130798-51-5.mol | [Molecular Weight]
302.11 |
| Chemical Properties | Back Directory | [Melting point ]
273-280℃ | [Boiling point ]
582.5±45.0 °C(Predicted) | [density ]
1.657±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
Soluble in DMSO (up to 15 mg/ml with warming) or in Ethanol (up to 10 mg/ml). | [form ]
solid | [pka]
4.04±0.30(Predicted) | [color ]
Off-white | [Stability:]
Stable for 2 years from date of pruchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Hazard Information | Back Directory | [Description]
NMDA receptors are neuroreceptors that have binding sites for glycine or D-serine as well as L-glutamate. MDL 29951 is an antagonist of NMDA receptors with high affinity for the glycine binding site (Ki = 140 nM). It is functional both in vitro and in vivo. MDL 29951 blocks NMDA receptor-dependent convulsions in audiogenic seizure-susceptible DBA/2J mice. It is used to evaluate the role of the glycine site of the NMDA receptor in neurological signaling. MDL 29951 is also an agonist of the G protein-coupled receptor GPR17 (EC50 values range from 7 nM to 6 μM, depending on the assay). GPR17 is thought to be involved in oligodendrocyte differentiation and myelin formation/repair. | [Uses]
MDL 29951 is an allosteric inhibitor of the enzyme fructose 1,6-bisphosphatase. | [IC 50]
NMDA Receptor | [storage]
Store at -20°C | [References]
1) Hennen?et al. (2013),?Decoding Signaling and Function of the Orphan Protein-Coupled Receptor GPR17 with a small molecule agonist; Sci. Signal.,?6?ra93
2) Salituro?et al. (1992)?3-(2-Carboxyindol-3-yl)propionic Acid-Based Antagonists of the N-Methyl-D-aspartic Acid Receptor Associated Glycine Binding Site; J. Med. Chem.,?35?1791 |
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