| Identification | Back Directory | [Name]
LHW090-A7 | [CAS]
1308256-94-1 | [Synonyms]
CS-2208
LHW090-A7
EOS-61103
(αS)-3'-Chloro-α-[[(1S)-2-ethoxy-1-methyl-2-oxoethyl]amino][1,1'-biphenyl]-4-propanoic acid
(S)-3-(3'-Chloro-[1,1'-biphenyl]-4-yl)-2-(((S)-1-ethoxy-1-oxopropan-2-yl)amino)propanoic acid
[1,1'-Biphenyl]-4-propanoic acid, 3'-chloro-α-[[(1S)-2-ethoxy-1-methyl-2-oxoethyl]amino]-, (αS)-
Sodium (2S)-3-(3'-chloro-[1,1'-biphenyl]-4-yl)-2-{[(2S)-1-ethoxy-1-oxopropan-2-yl]amino}propanoate
(alphaS)-3'-Chloro-alpha-[[(1S)-2-ethoxy-1-methyl-2-oxoethyl]amino][1,1'-biphenyl]-4-propanoic acid | [Molecular Formula]
C20H22ClNO4 | [MDL Number]
MFCD29044895 | [MOL File]
1308256-94-1.mol | [Molecular Weight]
375.85 |
| Chemical Properties | Back Directory | [solubility ]
DMSO: 5 mg/ml
Ethanol: 1 mg/mlPBS (pH 7.2): 10 mg/ml | [InChI]
InChI=1/C20H22ClNO4/c1-3-26-20(25)13(2)22-18(19(23)24)11-14-7-9-15(10-8-14)16-5-4-6-17(21)12-16/h4-10,12-13,18,22H,3,11H2,1-2H3,(H,23,24)/t13-,18-/s3 | [InChIKey]
PWYAUIUPDMSWJH-CODVNQPLNA-N | [SMILES]
C(O)(=O)[C@@H](N[C@@H](C)C(OCC)=O)CC1=CC=C(C2=CC=CC(Cl)=C2)C=C1 |&1:3,5,r| |
| Hazard Information | Back Directory | [Description]
LHW090-A7 is a compound developed as an inhibitor of neutral endopeptidase (NEP), an enzyme responsible for the metabolic inactivation of enkephalins. Inhibitors of NEP have been shown to increase plasma levels of endogenous atrial natriuretic peptides and, as such, are expected to induce natriuretic and diuretic effects. | [References]
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras. |
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