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1309241-34-6

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1309241-34-6 Structure

1309241-34-6 Structure
IdentificationBack Directory
[Name]

GRP-60367
[CAS]

1309241-34-6
[Synonyms]

GRP-60367
[Molecular Formula]

C21H27N3O2
[MDL Number]

MFCD19043296
[MOL File]

1309241-34-6.mol
[Molecular Weight]

353.46
Chemical PropertiesBack Directory
[Boiling point ]

547.9±50.0 °C(Predicted)
[density ]

1.16±0.1 g/cm3(Predicted)
[pka]

8.44±0.20(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Uses]

GRP-60367 is a first-in-class small-molecule rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains[1].
[Biological Activity]

GRP-60367 is a first-in-class small molecule rabies virus (RABV) entry inhibitor with nanomolar efficacy against certain RABV strains.
[in vitro]

GRP-60367 inhibits entry of a subset of RABV strains. GRP-60367 shows specific and potent anti-RABV activity of the scaffold, returning in dose-response assays EC 50 s ranging from 2 to 52 nM on different host cell lines.

[target]

RABV

[References]

[1] Venice Du Pont, et al. Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor. J Virol. 2020 Jun 16;94(13):e00321-20. DOI:10.1128/JVI.00321-20
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