1309241-34-6

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1309241-34-6 Structure

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302-H315-H319-H335
[Precautionary statements ] P261-P280-P301+P312-P302+P352-P305+P351+P338

Hazard Information	Back Directory
[Uses] GRP-60367 is a first-in-class small-molecule rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains[1].
[Biological Activity] GRP-60367 is a first-in-class small molecule rabies virus (RABV) entry inhibitor with nanomolar efficacy against certain RABV strains.
[in vitro] GRP-60367 inhibits entry of a subset of RABV strains. GRP-60367 shows specific and potent anti-RABV activity of the scaffold, returning in dose-response assays EC ₅₀ s ranging from 2 to 52 nM on different host cell lines.
[target] RABV
[References] [1] Venice Du Pont, et al. Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor. J Virol. 2020 Jun 16;94(13):e00321-20. DOI:10.1128/JVI.00321-20

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