| Identification | Back Directory | [Name]
2-hydroxypentanedioic acid | [CAS]
13095-47-1 | [Synonyms]
R-2-HYDROXYGLUTARATE
D-2-hydroxyglutarate
D--Hydroxyglutaric Acid
D-2-Hydroxyglutaric acid
D-α-Hydroxyglutaric Acid
(2R)-hydroxyglutaric acid
2-hydroxypentanedioic acid
(R)-2-Hydroxyglutaric acid
D-alpha-Hydroxyglutaric acid
(R)-alpha-Hydroxyglutaric acid
Pentanedioic acid, 2-hydroxy-, (2R)- | [Molecular Formula]
C5H8O5 | [MOL File]
13095-47-1.mol | [Molecular Weight]
148.11 |
| Chemical Properties | Back Directory | [Boiling point ]
394.2±27.0 °C(Predicted) | [density ]
1.508±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMF: 30 mg/mL; DMSO: 30 mg/mL; Ethanol: 30 mg/mL; PBS (pH 7.2): 10 mg/mL | [pka]
3.67±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
2-Hydroxypentanedioic Acid is a mouse metabolite | [Definition]
ChEBI:(R)-2-hydroxyglutaric acid is the (R)-enantiomer of 2-hydroxyglutaric acid. It has a role as an algal metabolite. It is an enantiomer of a (S)-2-hydroxyglutaric acid. | [in vivo]
D-α-Hydroxyglutaric acid strongly inhibits glucose utilization, CO2 production and the respiratory chain in rat cerebral cortex and human skeletal muscle, as well as in submitochondrial particles from bovine heart, suggesting an impairment of the aerobic metabolism[5].
D-α-Hydroxyglutaric acid has also been proposed as an endogenous excitotoxic organic acid because it significantly decreased cell viability in neuronal cultures from chick embryo telencephalons and from neonatal rat hippocampus through stimulation of specific NMDA glutamate receptors[5].
D-α-Hydroxyglutaric acid (0.01-1 mM) significantly increases chemiluminescence and thiobarbituric acid-reactive substances (TBA-RS) and decreased total antioxidant reactivity (TAR) values in the cortical supernatants in 30-day-old-rats[5]. | [IC 50]
Microbial Metabolite; Human Endogenous Metabolite | [storage]
Store at -20°C |
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