| Identification | Back Directory | [Name]
VBY-825 | [CAS]
1310340-58-9 | [Synonyms]
VBY-825
Pentanamide, N-cyclopropyl-3-[[(2R)-3-[(cyclopropylmethyl)sulfonyl]-1-oxo-2-[[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]amino]propyl]amino]-2-oxo-, (3S)- | [Molecular Formula]
C23H29F4N3O5S | [MOL File]
1310340-58-9.mol | [Molecular Weight]
535.55 |
| Chemical Properties | Back Directory | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (233.40 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
11.83±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
VBY-825 is a novel, reversible cathepsin inhibitor which has high potency against cathepsins B, L, S and V. VBY-825 is also a new and effective anti-tumor drug. | [in vivo]
VBY-825 (10 mg/kg, via gavage, once daily, 14 days) reduces pain behaviors in a mouse bone cancer model[2].
VBY-825 inhibits inflammation in mouse models of gout, peritonitis, and arthritis[3]. | Animal Model: | Mouse bone cancer model[2] | | Dosage: | 10 mg/kg; daily; 14 days | | Administration: | i.g. | | Result: | Reduced withdrawal and guarding of spontaneous bone cancer-induced pain. |
| [IC 50]
cathepsin K; cathepsin S | [storage]
Store at -20°C |
|
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
|