| Identification | Back Directory | [Name]
BACE1-IN-1 | [CAS]
1310347-50-2 | [Synonyms]
BACE1-IN-1
BACE-1-IN-1,BACE1 IN 1,BACE1IN1
2-Pyridinecarboxamide, N-[3-[(4R)-2-amino-5,5-difluoro-5,6-dihydro-4-methyl-4H-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyano- | [Molecular Formula]
C18H14F3N5O2 | [MDL Number]
MFCD30533310 | [MOL File]
1310347-50-2.mol | [Molecular Weight]
389.33 |
| Chemical Properties | Back Directory | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
9.95±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively. | [IC 50]
BACE1 | [References]
[1] Hilpert H, et al. β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J Med Chem. 2013 May 23;56(10):3980-95. DOI:10.1021/jm400225m |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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