| Identification | Back Directory | [Name]
PFM39 | [CAS]
1310744-67-2 | [Synonyms]
PFM39
PFM39 >=98% (HPLC)
4(5H)-Thiazolone, 2-amino-5-[(4-aminophenyl)methylene]-, (5Z)- | [Molecular Formula]
C10H9N3OS | [MDL Number]
MFCD31697706 | [MOL File]
1310744-67-2.mol | [Molecular Weight]
219.26 |
| Chemical Properties | Back Directory | [Melting point ]
>300 °C | [Boiling point ]
471.1±55.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO: 15mg/mL, clear | [form ]
Solid | [pka]
3.03±0.10(Predicted) | [color ]
Yellow to orange | [InChI]
1S/C10H9N3OS/c11-7-3-1-6(2-4-7)5-8-9(14)13-10(12)15-8/h1-5H,11H2,(H2,12,13,14)/b8-5- | [InChIKey]
QXOIZYPBCJHYLN-YVMONPNESA-N | [SMILES]
NC1=CC=C(/C=C2SC(NC\2=O)=N)C=C1 |
| Hazard Information | Back Directory | [Uses]
PFM39, a Mirin analog, is a potent and selective MRE11 exonuclease inhibitor. PFM39 inhibits phosphate rotation for dsDNA exonuclease activity. PFM39 does not inhibit TmMre11 or human MRE11/MRN endonuclease activity[1]. | [Biological Activity]
PFM39 is a potent cell-permeable Mirin analog th at selectively inhibits MRE11 exo-but not endo-nuclease activity. PFM39 targets MRE11 in a fashion similar to Mirinbut distinct from th at of PFM01 to allow a blockage of dsDNA phosphate backbone rotation and selective inhibition against MRE11 exo-but not endo-nuclease activity. FM39 potently impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR). | [storage]
4°C, protect from light | [References]
[1] Atsushi Shibata , et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9;53(1):7-18. DOI:10.1016/j.molcel.2013.11.003 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|