| Identification | Back Directory | [Name]
FK BINDING PROTEIN | [CAS]
131144-19-9 | [Synonyms]
FKBP1
FKBP1A
FKBP25
fkbp-12
FKBP-1A
Rotamase
12 kDa FKBP
FKBP3 human
Calstabin-1
PPIase FKBP3
PPIase FKBP1A
FK BINDING PROTEIN
Immunophilin FKBP12
FKBP1a/FKBP12 human
FK506 binding protein 3
fk-binding protein human
FK506-binding protein 1A
12 kDa FK506-binding protein
Human FKBP12 Protein, His Tag
Peptidyl-prolyl cis-trans isomerase FKBP1A
ANTI-FKBP12 (CENTER) antibody produced in rabbit
FK-BINDING PROTEIN HUMAN, RECOMBINANT*EX PRESSED IN | [MDL Number]
MFCD00131088 |
| Hazard Information | Back Directory | [Uses]
FKBP3 is part of a family of immunosuppressant receptors which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 accelerates the folding of proteins. FKBP3 is part of the immunophilin protein family, which participates in immunoregulation and fundamental cellular processes concerning protein folding and trafficking. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a greater affinity for rapamycin than for FK506 and therefore is a significant protein for immunosuppression by rapamycin. | [Biological Activity]
FKFBP1A (FK506-binding protein 1A) is a peptidyl-prolyl cis-trans isomerase. It interacts with the ryanodine receptor (RyR1) and helps in maintaining intracellular Ca2+ homeostasis. It is also involved in protein foldingcell cycle and protein trafficking. In neurodegenerative diseasesFKFBP1A is dysregulated and might be associated with the pathogenesis. In human cell linesit controls the localization and processing of amyloid precursor proteinand thus might be involved in the pathogenesis of Alzheimer′s disease. FKFBP1A is also involved in Huntington′s disease. It plays a role in the structural properties and proteotoxicity of mHTT (mutant huntingtin) aggregates. |
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Biolab Reagents
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ACROBiosystems
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