| Identification | Back Directory | [Name]
N-(3-Azidopropyl)-4-(2,6-di-tert-butyl-4-(6-(4-Methylpiperazin-1-yl)-1H-benzo[d]iMidazol-2-yl)phenoxy)butanaMide | [CAS]
1311982-88-3 | [Synonyms]
MIR96-IN-1
MIR96 inhibitor 1
N-(3-Azidopropyl)-4-(2,6-di-tert-butyl-4-(6-(4-Methylpiperazin-1-yl)-1H-benzo[d]iMidazol-2-yl)phenoxy)butanaMide | [Molecular Formula]
C33H48N8O2 | [MDL Number]
MFCD28359093 | [MOL File]
1311982-88-3.mol | [Molecular Weight]
588.787 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 100 mg/mL (169.84 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
MIR96-IN-1 is a selective inhibitor of the biogenesis of microRNA-96. It acts by upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells. | [Uses]
MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with Kds of 1.3, 9.4, 3.4, 1.3 and 7.4 μM for RNA1, RNA2, RNA3, RNA4 and RNA5, respectively[1]. MIR96-IN-1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [storage]
Store at -20°C | [References]
[1] Sai Pradeep Velagapudi,et al. Design of a small molecule against an oncogenic noncoding RNA. Proc Natl Acad Sci U S A. 2016 May 24;113(21):5898-903. DOI:10.1073/pnas.1523975113
[2] Christopher L Haga, et al. Small Molecule Inhibition of miR-544 Biogenesis Disrupts Adaptive Responses to Hypoxia by Modulating ATM-mTOR Signaling. ACS Chem Biol. 2015 Oct 16;10(10):2267-76. DOI:10.1021/acschembio.5b00265 |
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