| Identification | Back Directory | [Name]
MK-8457 | [CAS]
1312518-84-5 | [Synonyms]
MK-8457
Cyclohexanecarboxylic acid, 4-hydroxy-2,2-dimethyl-4-[5-[3-methyl-5-[[4-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-2-thiazolyl]-, (1S,4R)- | [Molecular Formula]
C24H25F3N4O3S | [MOL File]
1312518-84-5.mol | [Molecular Weight]
506.54 |
| Hazard Information | Back Directory | [Uses]
MK-8457 is a dual SYK/ZAP70 inhibitor. MK-8457 can be used for research of rheumatoid arthritis[1]. | [References]
[1] Coffey G, et al. PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers. J Clin Pharmacol. 2017 Feb;57(2):194-210. DOI:10.1002/jcph.794 |
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